Mouth Ulcers Research Today is a free monthly online journal that collates and summarizes the latest research about Mouth Ulcers, including details on treatment, causes, medication, remedies.

Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models.

Sulaiman MR, Zakaria ZA, Daud IA, Ng FN, Ng YC, Hidayat MT

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. mrs@medic.upm.edu.my

This study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of Kaempferia galanga leaves using various animal models. The extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dH(2)O) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot-plate and formalin tests, with activity observed in all tests occurring in a dose-dependent manner. Furthermore, the antinociceptive activity of K. galanga extract was significantly (P < 0.05) reversed when prechallenged with 10 mg/kg naloxone. The extract also produced a significantly (P < 0.05) dose-dependent anti-inflammatory activity when assessed using the carrageenan-induced paw-edema test. In conclusion, this study demonstrated that K. galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc.

Published 11 April 2008 in Nat Med (Tokyo), 62(2): 221-7.
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Articles on Mouth Ulcers published 26 March 2008:

Pattern of uveitis in Behçet's disease in a referral center in Tunisia, North Africa.   Int Ophthalmol.

The purpose of this study was to analyze the pattern of uveitis in Behçet's disease in Tunisia, North Africa. We retrospectively reviewed the clinical records of 62 patients (111 eyes) diagnosed with Behçet's uveitis (BU) at the Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia, between January 1995 and December 2006. Forty-seven of 62 patients (75.8%) were men and 15 (24.2%) were women. Mean age at onset was 29.3 years. The average follow-up was 75.6 ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 4 March 2008:

Significance of anti-cell membrane-associated DNA (mDNA) antibodies in systemic lupus erythematosus.   Clin Rheumatol, 27(2): 183-187.

The aim of this study was to evaluate the value of anti-cell membrane-associated DNA (mDNA) antibodies in the diagnosis of systemic lupus erythematosus (SLE). Antibodies against mDNA were detected with indirect immunofluorescence assay in 207 SLE, 167 other rheumatic diseases, and 82 healthy controls. Association of clinical features and anti-mDNA antibodies was analyzed. The prevalence of anti-mDNA antibodies was 73.3% in SLE, 8.3% in Sjögren's syndrome, and 4.8% in rheumatoid arthritis. The ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 12 February 2008:

Ecstasy (MDMA) and oral health.   Br Dent J, 204(2): 77-81.

3,4-methylenedioxymethamphetamine (MDMA), more commonly known as 'ecstasy' or XTC, is frequently used by young adults in the major cities. Therefore, it is likely that dentists might be confronted with individuals who use ecstasy. This review describes systemic and oral effects of ecstasy. Life-threatening complications include hyperthermia, hyponatraemia and liver failure. In addition, psychotic episodes, depression, panic disorders and impulsive behaviour have been reported. Oral effects ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 11 February 2008:

Ulceration of gingival mucosa after topical application of EMLA: report of four cases.   Br Dent J, 204(3): 133-4.

This study reports four cases of mucosa ulceration after a 30-minute application of EMLA (0.3 g) as a topical anaesthetic in dentistry. The subjects returned the next day with a white ulceration and desquamation on the application site. EMLA cream should not be applied to the oral mucosa for 30 minutes. [Abstract] [Full-text]

Articles on Mouth Ulcers published 15 January 2008:

Myelodysplastic syndrome with trisomy 8 associated with Behçet syndrome: an immunologic link to a karyotypic abnormality.   Pediatr Blood Cancer, 50(3): 649-51.

Myelodysplastic syndrome (MDS) in children is often associated with chromosomal anomalies and trisomy 8 is a characteristic karyotypic feature in up to 20% of the cases. Behçet disease is a rare multisystem inflammatory disorder characterized by recurrent mouth and genital ulcers. MDS with trisomy 8 has been observed in adult patients with Behçet syndrome with some cases developing prior to the clinical manifestations of the latter. We present a female with a similar association and explain ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 14 January 2008:

Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.   Dig Liver Dis, 40(2): 104-7.

AIMS: Oral mucosal lesions may be markers of chronic gastrointestinal disorders, such as those causing malabsorption. Our objectives were to assess the prevalence of recurrent oral aphthous-like ulcers in coeliac disease patients living in the Mediterranean area, and to evaluate the impact of a gluten-free diet. METHODS: A test group of 269 patients (age range 3-17 years) with coeliac disease confirmed both serologically and histologically was compared with a control group of 575 otherwise ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 26 December 2007:

Clinical evaluation of oral chronic graft-versus-host disease.   Biol Blood Marrow Transplant, 14(1): 110-5.

Oral chronic graft-versus-host disease (cGVHD) is a significant and serious complication following allogeneic hematopoietic stem cell transplantation (HSCT). The purpose of this study was to characterize the distribution, type, and extent of lesions and their correlation with patient-reported symptoms such as pain and discomfort. The effect of time since transplantation on these measures was also assessed. Consecutive patients with oral cGVHD referred to the Center for Oral Disease at Brigham ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 29 November 2007:

Demographic and clinical properties of juvenile-onset Behçet's disease: A controlled multicenter study.   J Am Acad Dermatol.

BACKGROUND: Behçet's disease (BD) is a multisystemic inflammatory disorder of unknown origin. The disease usually occurs between the second and the fourth decades, whereas it is uncommon in children. OBJECTIVE: In this multicenter study, we aimed to describe the demographic and clinical features along with severity in juvenile- versus adult-onset BD. METHODS: Patients with initial symptoms at age 16 years or younger were considered as having juvenile-onset BD. In all, 83 patients with ... [Abstract] [Full-text]

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