Mouth Ulcers Research Today is a free monthly online journal that collates and summarizes the latest research about Mouth Ulcers, including details on treatment, causes, medication, remedies.

Supportive care of a critically ill child.

Saharan S, Lodha R, Kabra SK

Division of Pulmonology and Intensive care, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

The goal of pediatric intensive care is early identification, severity assessment and resuscitation of critical patients by utilizing standardized protocols. The primary or precipitating disorder should be the focus of attention and specific intervention. But in order to provide holistic care to a patient, due attention should also be rendered to supportive care. Monitoring of sick children in PICU is an essential part of management. Various monitoring technologies add to the clinical monitoring but cannot replace clinical monitoring. The treating team should follow a checklist to ensure all aspects of supportive care are taken care of in every patient. Due attention should be paid to glucose control, skin and eye care, oral hygiene, prevention of stress ulcer, care of various lines and catheters and prevention of nosocomial infections.

Published 6 May 2011 in Indian J Pediatr, 78(5): 585-92.
Full-text of this article is available online (may require subscription).

Articles on Mouth Ulcers published 5 May 2011:

Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients.   Drugs Aging, 28(5): 345-67.

Among the antidepressants, the selective serotonin reuptake inhibitors (SSRIs) are often preferred to other classes of antidepressants in the treatment of depression in the elderly because of their better safety profile. Most of the known effects of SSRIs, either beneficial or adverse, are linked to their inhibitory action on the serotonin reuptake transporter (5-HTT). This reuptake mechanism is present not only in neurons but also in other cells such as platelets. Serotoninergic mechanisms ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 4 May 2011:

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?   Dermatology, 222(2): 113-8.

Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in ... [Abstract] [Full-text]

Effects of Intravenously Administered Esomeprazole Sodium on Gastric Juice pH in Adult Female Horses.   J Vet Intern Med, 25(3): 558-62.

Background: Gastric ulcers are common in horses and treatment of horses that cannot be administered oral medication can be problematic. Objectives: To evaluate the efficacy of esomeprazole sodium administered intravenously on gastric juice pH and gastric ulcer scores in horses. Animals: Twelve adult female Quarter Horses. Methods: Esomeprazole sodium (0.5 mg/kg IV) was administered once daily to 8 horses (treatment group) and saline (5 mL IV) was administered to 4 horses (control group) for ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 2 May 2011:

Food-Grade Expression of Helicobacter pylori UreB Subunit in Lactococcus lactis and its Immunoreactivity.   Curr Microbiol, 62(6): 1726-31.

Helicobacter pylori is the principal cause of chronic active gastritis, peptic ulcer, and gastric cancer. To develop an oral vaccine against H. pylori infection, we had expressed the H. pylori ureB gene (Genbank accession no. FJ436980) in nisin-controlled expression vectors using Lactococcus lactis NZ3900 as host. The ureB gene was amplified by PCR from a H.pylori strain MEL-Hp27. Then the ureB gene was fused translationally downstream of the nisin-inducible promoter nisA in a L. lactis plasmid ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 22 April 2011:

Gastric Ulcer Revealed by Computed Tomography in a Patient with Tongue Cancer after Percutaneous Gastrostomy.   Case Rep Gastroenterol, 5(1): 136-138.

With the advances in computed tomography (CT) imaging, CT can result in precise imaging, even of the gastrointestinal tract. However, the diagnostic quality of endoscopy is superior to CT because of precise mucosal observations or biopsy procedure. In the present case, CT was useful in the diagnosis of a gastric ulcer because endoscopy was deemed too difficult to perform due to tongue cancer occupying the oral space. Three-dimensional reconstruction of the CT images revealed an ulcerous lesion ... [Abstract] [Full-text]

Gastric ulcer revealed by computed tomography in a patient with tongue cancer after percutaneous gastrostomy.   Case Rep Gastroenterol, 5(1): 136-8.

With the advances in computed tomography (CT) imaging, CT can result in precise imaging, even of the gastrointestinal tract. However, the diagnostic quality of endoscopy is superior to CT because of precise mucosal observations or biopsy procedure. In the present case, CT was useful in the diagnosis of a gastric ulcer because endoscopy was deemed too difficult to perform due to tongue cancer occupying the oral space. Three-dimensional reconstruction of the CT images revealed an ulcerous lesion ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 14 April 2011:

Natural history, management and pharmacokinetics of Everolimus-induced-oral ulcers: Insights into compliance issues.   Eur J Cancer.

BACKGROUND: Oral Ulcers is a well-recognised adverse event (AE) of mTOR inhibitors. Paradoxically, little is known about its natural history, risk factors, and basic management. PATIENTS AND METHODS: AEs of 79 patients prospectively enrolled in 6 phase I-II studies testing Everolimus were reviewed. The following parameters were analysed: incidence, severity, duration and associated AE. The association between OU and Everolimus dose, pharmacokinetics and the effectiveness of empiric treatments ... [Abstract] [Full-text]

Oral disease and risk of oesophageal and gastric cancer in a nationwide nested case-control study in Sweden.   Eur J Cancer.

The association between the exposure to oral disease and the outcomes of oesophageal and gastric cancer was examined in a Swedish nationwide inpatient register-based nested case-control study in 1964-2008. The study included 6,156 oesophageal squamous-cell carcinoma cases that were compared with 29,993 controls, 2684 oesophageal adenocarcinoma cases that were compared with 15,036 controls and 38,308 gastric cancer cases that were compared with 99,991 controls. For oesophageal squamous cell ... [Abstract] [Full-text]

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