Mouth Ulcers Research Today is a free monthly online journal that collates and summarizes the latest research about Mouth Ulcers, including details on treatment, causes, medication, remedies.

Epidemiological Link between Gastric Disease and Polymorphisms in VacA and CagA.

Jang S, Jones KR, Olsen CH, Joo YM, Yoo YJ, Chung IS, Cha JH, Merrell DS

Department of Oral Biology, Yonsei University College of Dentistry, 134 Sinchon-dong, Seodaemoon-gu, Seoul 120-752, South Korea. Jcha@yuhs.ac.

Gastritis, peptic ulcer disease, and gastric cancer are a few of the diverse disease manifestations that have been shown to be associated with infection by Helicobacter pylori. Why some individuals develop more severe forms of disease remains largely unknown. In this study, 225 South Korean strains were genotyped for vacA and then analyzed to determine if particular genotypes varied across disease state, sex, or cagA allele. Of these strains, 206 strains carried an s1/i1/m1 allele, 11 strains carried an s1/i1/m2 allele, and 8 strains carried an s1/i2/m2 allele. By using Fisher's exact test, a statistical association between variations in the cagA and vacA alleles was identified (P = 0.0007), and by using log linear modeling, this variation was shown to affect the severity of disease outcome (P = 0.027). Additionally, we present evidence that variation within the middle region of VacA contributes significantly to the distribution of vacA alleles across gender (P = 0.008) as well as the association with disease outcome (P = 0.011). In this South Korean population, the majority of H. pylori strains carry the vacA s1/i1/m1 allele and the CagA EPIYA-ABD allele. These facts may contribute to the high incidence of gastric maladies, including gastric cancer.

Published 1 February 2010 in J Clin Microbiol, 48(2): 559-67.
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Articles on Mouth Ulcers published 29 January 2010:

Gastroprotective and antisecretory effects of Ailanthus excelsa (Roxb).   J Nat Med, 64(1): 109-113.

Ailanthus excelsa (Roxb), an Egyptian medicinal species highly important for treating numerous diseases, was investigated against experimentally induced gastric ulcer in rodents. We evaluated the gastroprotective effect of four extracts (petroleum ether, diethyl ether, chloroform, and methanol) of A. excelsa bark by using the ethanol-induced gastric lesion model. The pretreatment of animals with methanolic, petroleum ether, and chloroformic extracts (100 mg/kg, oral (p.o.)) from A. excelsa ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 27 January 2010:

Potential of Endogenous Regenerative Technology for in situ regenerative medicine.   Adv Drug Deliv Rev.

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Articles on Mouth Ulcers published 21 January 2010:

The efficacy of a paste containing Myrtus communis (Myrtle) in the management of recurrent aphthous stomatitis: a randomized controlled trial.   Clin Oral Investig, 14(1): 65-70.

Recurrent aphthous stomatitis (RAS) is a common, painful, and ulcerative disorder of the oral cavity with unknown etiology. Treatment is a highly controversial topic. The aim of this study was to evaluate the clinical efficacy of a novel paste containing Myrtus communis (Myrtle) in the treatment of recurrent aphthous stomatitis. Myrtle is a particular herb used in some cultures as treatment for mouth ulcers. The study was a randomized, double-blind, controlled before-after clinical trial. ... [Abstract] [Full-text]

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Articles on Mouth Ulcers published 19 January 2010:

The potential therapeutic effect of melatonin in gastro-esophageal reflux disease.   BMC Gastroenterol, 10(1): 7.

ABSTRACT: BACKGROUND: Gastro-Esophageal Reflux Disease (GERD) defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Many drugs are used for the treatment of GERD such as omeprazole (a proton pump inhibitor) which is a widely used antiulcer drug demonstrated to protect against esophageal mucosal injury. Melatonin has been found to protect the gastrointestinal mucosa from oxidative damage caused by reactive oxygen species in ... [Abstract] [Full-text]

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Articles on Mouth Ulcers published 18 January 2010:

Oral administration and external application of Chinese drugs combined with micro-invasive operation for the treatment of varicose ulcers in the lower extremities.   Chin J Integr Med, 15(6): 420-5.

OBJECTIVE: To evaluate the clinical therapeutic effects of oral administration and external application of Chinese drugs combined with micro-invasive surgery for the treatment of varicose ulcers in the lower extremities (ecthyma). METHODS: A total of 152 patients (163 limbs) suffering from varicose ulcers on the lower limbs were assigned to two groups according to the patients' willingness. The 102 cases (109 limbs) in the treatment group underwent the method of endovenous microwave closure of ... [Abstract] [Full-text]

Articles on Mouth Ulcers published 12 January 2010:

Systems initiatives reduce healthcare-associated infections: a study of 22,928 device days in a single trauma unit.   J Trauma, 68(1): 23-31.

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